Topics

urology
To observe the impact of hormonal treatment (HT) on voiding patterns and renal circadian rhythms in postmenopausal women with and without nocturnal polyuria (NP). Conclusion: HT led to a significant reduction in both fluid intake and daytime frequency. In women without NP, HT led to a disruption of the circadian rhythms of water and salt diuresis. In patients with NP, a limited nor- malisation of the circadian rhythm of free water clearance was observed after three months of HT.
17/06/2022,
Serge Rozenberg
Serge Rozenberg
screening
In an organized mammography screening programme interval cancers have a worse prognostic tumour profile than screen-detected cancers. Analysis of molecular subtype distributions versus breast density reveals a higher percentage of the triple-negative phenotype in low-density breasts. The observations support arguments against the prolongation of screening intervals in low-density breasts.
15/04/2022,
Serge Rozenberg
Serge Rozenberg
Breast cancer (BC) screening has been associated with reduced mortality and morbidity. This study compares tumor characteristics and treatment morbidity in screened versus diagnosed women. Materials and methods This retrospective study, conducted between 2010 and 2013, included 666 BC screened or diagnosed patients. We compared patients and tumors characteristics and received treatments. We also analyzed the results after excluding patients at risk of BC and conducted a multivariate analysis to assess odds ratios (OR). Results Screened women had smaller tumors (16,5 vs 22,6 mm, p<0.001), of lower grade (p<0.001) with a lower proliferation index (PI) (p<0.001) than diagnosed women. Screened women were more frequently treated using conservative surgery (82.8% vs 59.7%, p<0.001), needed less often axillary dissection (15.1% vs 35.4%, p<0.001) and less often chemotherapy (20.8% vs 48.3% p<0.001) than diagnosed women. In the multivariate analysis after adjustment for age and BC history, diagnosed women had increased (OR: 4.79, 95% IC: 3.19–7,18) risk to be administered chemotherapy and to undergo axillary dissection (OR: 4.18, 95% IC: 1.56–11.17) than screened women. Conclusion Patients should be informed about the benefts in terms of morbidity that screening confers to them.
14/05/2022,
Serge Rozenberg
Serge Rozenberg
POI
Premature ovarian insufficiency (POI), a condition affecting up to 1% of women by the age of 40 years, is characterized by an extremely low chance of spontaneous pregnancy. Currently, fertility restoration options are virtually nonexistent for this population.
06/10/2022,
Axelle Pintiaux
Axelle Pintiaux
Osteoporosis
To provide updated evidence-based guidelines for the management of osteoporosis in postmenopausal women in Belgium. Osteoporosis screening using clinical risk factors should be considered. Patients with a recent (<2 years) major osteoporotic fracture were considered at very high and imminent risk of future fracture. The combination of bone mineral density measured by dual-energy X-ray absorptiometry and 10-year fracture risk was used to categorize patients as low or high risk. Patient education, the combination of weight-bearing and resistance training, and optimal calcium intake and vitamin D status were recommended. Antiresorptive and anabolic osteoporosis treatment should be considered for patients at high and very high fracture risk, respec- tively. Follow-up should focus on compliance, and patient-tailored monitoring should be considered. Conclusion: BBC guidelines and 25 guideline recommendations bridge the gap between research and clinical practice for the screening, diagnosis, and management of osteoporosis.
06/05/2020,
Serge Rozenberg
Serge Rozenberg
Menopause treatment
This prospective, randomized, placebo-controlled study recruited 80 healthy postmenopausal women. We observed a trend towards lower insulin levels in an oral glucose tolerance test among women taking menopausal hormone therapy. The peak insulin levels in the women taking menopausal hormone therapy at the end of the study period were significantly lower than at baseline, with a non-significant trend towards a lower total area under the curve. Menopausal hormone therapy increased glucose levels.
21/08/2020,
Serge Rozenberg
Serge Rozenberg